Beijing, 18 May 2022 (TDI): Chinese researchers have created a mosaic nanoparticle candidate vaccine that protects against Covid-19 variant infections.
The quadrivalent mosaic nanoparticle vaccine was developed by scientists from Sun Yat-sen University which is affiliated with Guangzhou Medical University, and the Guangdong Provincial Center for Disease Control and Prevention.
It contains spike proteins from the SARS-CoV-2 prototype as well as three major variants: Alpha, Beta, and Gamma.
Because the virus spike protein is known to play an important role in viral attachment and fusion with the host cell, most antibodies that neutralize viral infection target it.
However, mutations in viral types found on the spike protein frequently result in broad antibody resistance and immunological escape from vaccinated sera, posing a new threat, according to research reported recently in the journal “Nature Communications.”
The nanoparticle generated similar or superior neutralizing antibodies against variant strains in mice and non-human primates with just a minor loss in neutralization against the ancestor strain.
The vaccine was also evaluated for Omicron and Lambda coronaviruses. The two variants only reduced the neutralization efficiency of vaccine-generated sera by a small proportion.
Demonstrating that the induced sera might trigger broadly protective antibody production against circulating variants. According to the researchers, the data show the feasibility of producing multivalent vaccines against pandemic and likely pre-emergent SARS-CoV-2 variants.
There are numerous hypotheses on the Covid-19 vaccine. Getting vaccinated against Covid-19 is a safer and more reliable strategy to establish immunity than getting sick with the virus. Covid-19 immunization protects by eliciting an immune system response without requiring to become unwell.
The World Health Organization (WHO) and experts from throughout the world, however, are urging people to get vaccinated as the best way to end the pandemic. The sooner people are inoculated, the faster it will be feasible to prevent the disease’s spread.
